Clinical characteristics and viral kinetics of DENV-1 and DENV-4 congenital dengue in two newborns

The cases reported the clinical characteristics and viral kinetics of DENV-1 and DENV-4 in two cases of congenital dengue. We describe two neonates bom to mothers with recent dengue infections, highlighting their clinical presentation, serological progression and outcomes. Both neonates had early onset of symptoms, with one tested positive for DENV-4 and the other for DENV-1. Both experienced thrombocytopaenia without signs of haemoconcentration and recovered uneventfully. Congenital dengue, although rare, should be considered in neonates with fever and other suggestive symptoms in dengue-endemic areas. The two reported cases are unique in that both had congenital dengue fever with different serotypes, yet demonstrated prolonged NS1 antigen positivity and delayed seroconversion.

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