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2-dodecanol (decyl methyl carbinol) inhibits hyphal formation and SIR2 expression in C. albicans


Citation

Lim, Crystale Siew Ying and Wong, Won Fen and Rosli, Rozita and Ng, Kee Peng and Seow, Heng Fong and Chong, Pei Pei (2009) 2-dodecanol (decyl methyl carbinol) inhibits hyphal formation and SIR2 expression in C. albicans. Journal of Basic Microbiology, 49 (6). pp. 579-583. ISSN 0233-111X; ESSN: 1521-4028

Abstract / Synopsis

Candida albicans is capable of undergoing yeast-hypha transition to attain pathogenicity in humans. In this study, we investigated the differential expression of CaSIR2 via quantitative real-time PCR (qPCR), during yeast-hypha transition with and without the presence of 2-dodecanol. SIR2 transcript levels were found to be significantly enhanced after hyphal induction as compared to the yeast form. This study found that 2-dodecanol is able to inhibit hyphal development and block SIR2 up-regulation, even in hyphal-inducing growth conditions. We suggest that SIR2 may be involved in Candida albicans quorum-sensing and serum-induced yeast-hyphae transition via the Ras1-cAMP-Efg1 signalling cascade.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1002/jobm.200900035
Publisher: Wiley-VCH Verlag GmbH & Co. KGaA
Keywords: Candida albicans; SIR2 gene; Quantitative real-time PCR; Gene expression; Dodecanol
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 22 Jun 2015 07:52
Last Modified: 28 Mar 2017 21:51
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1002/jobm.200900035
URI: http://psasir.upm.edu.my/id/eprint/12634
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