Citation
Abstract
RNA interference regulates gene expression by selectively silencing target genes through the introduction of small RNA molecules, such as microRNA, small interfering RNA and short hairpin RNA. These molecules offer significant therapeutic potential for diverse human ailments like cancer, viral infections and neurodegenerative disorders. Whilst non-viral vectors like nanoparticles have been extensively explored for delivering these RNAs, viral vectors, with superior specificity and delivery efficiency, remain less studied. This review examines current viral vectors for small RNA delivery, focusing on design strategies and characteristics. It compares the advantages and drawbacks of each vector, aiding readers in selecting the optimal one for small RNA delivery.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Subject: | Microbiology |
| Subject: | Microbiology (medical) |
| Divisions: | Faculty of Biotechnology and Biomolecular Sciences Institute of Bioscience |
| DOI Number: | https://doi.org/10.1099/jmm.0.001972 |
| Publisher: | Microbiology Society |
| Keywords: | DNA viruses; Drosha; Gene silencing; RNA viruses; Small RNA; Viral vector |
| Sustainable Development Goals (SDGs): | SDG 3: Good Health and Well-being, SDG 9: Industry, Innovation and Infrastructure, SDG 12: Responsible Consumption and Production |
| Depositing User: | Ms. Nur Faseha Mohd Kadim |
| Date Deposited: | 06 May 2026 08:58 |
| Last Modified: | 06 May 2026 08:58 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1099/jmm.0.001972 |
| URI: | http://psasir.upm.edu.my/id/eprint/124814 |
| Statistic Details: | View Download Statistic |
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