Curculatifolia, a new norlignan derivative from Curculigo latifolia using MS/MS-based molecular networking discovery

Citation

Mad Nasir, Nadiah and Kassim, Nur Kartinee and Hasan, Hanan and Devakrishnan, Pavithren and Ismail, Intan Safinar (2025) Curculatifolia, a new norlignan derivative from Curculigo latifolia using MS/MS-based molecular networking discovery. Phytochemistry Letters, 70. art. no. 103051. pp. 1-8. ISSN 1874-3900; eISSN: 1876-7486

Abstract

The Curculigo genus is a source of secondary metabolites with various bioactivities, including antidiabetic, antibacterial, anti-inflammatory, and antioxidant properties. In this study, we investigated Curculigo latifolia from Western Malaysia using LC-MS/MS and molecular networking (MN) analysis. The analysis revealed two major clusters, norlignans and phenolic glycosides, in fractions F14–17 and L2. Furthermore, this paper presents the first comparative study of sinensigenin A, the most abundant compound in the rhizome fraction exhibiting antioxidant activity, and sinensigenin B, the most abundant compound in the leaf fraction, which demonstrates activity against Staphylococcus aureus and Bacillus subtilis. We isolated one new compound, curculatifolia (27), using an MN-guided approach and characterized it through spectroscopic techniques (NMR, FTIR, and MS).

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Additional Metadata

Item Type:	Article
Subject:	Biotechnology
Subject:	Biochemistry
Subject:	Agronomy and Crop Science
Divisions:	Faculty of Food Science and Technology Faculty of Science Halal Products Research Institute
DOI Number:	https://doi.org/10.1016/j.phytol.2025.103051
Publisher:	Elsevier
Keywords:	Curculigo; GNPS; LC-MS/MS; Molecular networking; Norlignans; Phenolic glycosides
Sustainable Development Goals (SDGs):	SDG 3: Good Health and Well-being, SDG 15: Life on Land, SDG 12: Responsible Consumption and Production
Depositing User:	MS. HADIZAH NORDIN
Date Deposited:	03 Jun 2026 06:19
Last Modified:	03 Jun 2026 06:19
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.phytol.2025.103051
URI:	http://psasir.upm.edu.my/id/eprint/124347
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