UPM Institutional Repository

Skin-penetrating peptides (SKPs): enhancing skin permeation for transdermal delivery of pharmaceuticals and cosmetic compounds


Citation

Muhammad, Ameerah Montree and Ismail, Alif and Chong, Pei Pei and Yap, Wei Hsum and Muhamad, Azira and Alitheen, Noorjahan Banu and Kam, Antony and Loo, Shining and Lee, Khai Wooi (2025) Skin-penetrating peptides (SKPs): enhancing skin permeation for transdermal delivery of pharmaceuticals and cosmetic compounds. International Journal of Pharmaceutics, 672. art. no. 125339. ISSN 0378-5173; eISSN: 1873-3476

Abstract

Skin-penetrating peptides (SKPs) are emerging as a promising class of permeation enhancers that can facilitate macromolecule delivery across the skin. Although their pharmaceutical applications are under extensive study, SKPs are crucial for enhancing skin permeability, enabling larger molecules to penetrate the stratum corneum. This review explores the transformative role of SKPs in non-invasive transdermal drug delivery. Drawing from an extensive collection of literature, it provides insights into the current usage and application of SKPs as tools to enhance skin permeability and facilitate the delivery of larger molecules. Additionally, it highlights the opportunities, challenges, and future directions for SKP applications in transdermal drug delivery.


Download File

[img] Text
124284.pdf - Published Version
Restricted to Repository staff only
Download (5MB)

Additional Metadata

Item Type: Article
Subject: Pharmaceutical Science
Divisions: Faculty of Biotechnology and Biomolecular Sciences
DOI Number: https://doi.org/10.1016/j.ijpharm.2025.125339
Publisher: Elsevier
Keywords: Drug delivery system; Functional peptides; Non-invasive drug delivery; Permeation enhancers; Skin delivery; Transdermal delivery
Sustainable Development Goals (SDGs): SDG 3: Good Health and Well-being, SDG 9: Industry, Innovation and Infrastructure, SDG 12: Responsible Consumption and Production
Depositing User: Ms. Nur Faseha Mohd Kadim
Date Deposited: 07 May 2026 00:58
Last Modified: 07 May 2026 00:58
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.ijpharm.2025.125339
URI: http://psasir.upm.edu.my/id/eprint/124284
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item