Centella asiatica as a potential neurotherapeutic adjunct in oxidative stress–targeted stem cell therapies

Neurodegenerative disorders are marked by the progressive deterioration of neurons in the central nervous system, often driven by oxidative stress (OS), which disrupts cellular redox balance, damages neural tissue, and fuels chronic neuroinflammation. Despite ongoing active research on possible treatments, there is still no known cure for these diseases, necessitating innovative therapeutic approaches, including the use of herbal extracts. This review explores the potential of Centella asiatica, a traditional medicinal plant rich in antioxidant compounds, as a neuroenhancer in neurotherapeutic strategies targeting OS. By scrutinising the intricate interplay of Centella asiatica's phytochemical constituents, this review aims to give insights into how this natural extract could offer innovative therapeutic strategies for addressing the complexities and effective treatment modalities of neurodegenerative diseases, potentially via stem cell–based cellular and acellular therapies.

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