Oxidative stress in Down syndrome: unraveling the intertwined pathways for novel target identification

Citation

Lim, Cheng Wei and Abdul Hamid, Hafizah and Ling, King Hwa and Cheah, Pike See (2025) Oxidative stress in Down syndrome: unraveling the intertwined pathways for novel target identification. Current Opinion in Physiology, 46. art. no. 100864. pp. 1-9. ISSN 2468-8681; eISSN: 2468-8673

Abstract

Down syndrome (DS) individuals experience chronic and widespread oxidative stress across all organs throughout their lives. While the cause of oxidative stress in DS may be difficult to pinpoint, the myriad perturbations investigated to date share commonalities in terms of their mechanisms. Recent studies highlight five main mechanisms of oxidative stress in DS, namely increased production of reactive oxygen species (ROS), decreased antioxidant defense, impaired mitochondrial biology, defective cellular clearance, and altered metabolism. These mechanisms interact with one another to bring about the overproduction of ROS or a reduction in their clearance. This review attempts to summarize the latest perspective and findings regarding these five mechanisms with emerging evidence within the past five years (2020 to 2025).

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Additional Metadata

Item Type:	Article
Subject:	Physiology
Subject:	Physiology (medical)
Divisions:	Faculty of Medicine and Health Science Malaysian Research Institute on Ageing
DOI Number:	https://doi.org/10.1016/j.cophys.2025.100864
Publisher:	Elsevier
Keywords:	Down syndrome; Oxidative stress; Reactive oxygen species; Antioxidant defense; Mitochondrial dysfunction; Cellular clearance; Metabolism; Novel targets; Disease mechanisms; Trisomy 21
Sustainable Development Goals (SDGs):	SDG 3: Good Health and Well-being, SDG 10: Reduced Inequalities, SDG 17: Partnerships for the Goals
Depositing User:	MS. HADIZAH NORDIN
Date Deposited:	23 Jun 2026 05:35
Last Modified:	23 Jun 2026 05:35
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.cophys.2025.100864
URI:	http://psasir.upm.edu.my/id/eprint/124210
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