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Evidence Of Astrocytic Reactivity During Vestibular Compensation


Lee, Su Ann (2003) Evidence Of Astrocytic Reactivity During Vestibular Compensation. Masters thesis, Universiti Putra Malaysia.


Vestibular compensation is the spontaneous disappearance of postural and oculomotor imbalance exhibited by the vestibular system in response to decreased inputs from the labyrinths. Astrocytes in the vestibular nuclei have been reported to have a role in the plasticity of the central nervous system. The present study was conducted to investigate the behavioural changes of mice and the morphological changes and distribution of astrocytes following unilateral labyrinthectomy. Thirty-five mice (Mus musculus) underwent unilateral labyrinthectomy (UL) and fourteen underwent sham-operation. Their behavioural changes following surgical removal of labyrinths, or sham-operation, were observed. The UL groups displayed behavioural changes including head tilt, circular walking, barrel-rolling and extension and flexion of limbs. These behavioural symptoms disappeared within approximately 3 hours. For the sham-operated animals, these symptoms were absent.

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Additional Metadata

Item Type: Thesis (Masters)
Call Number: FPSK(M) 2003 5
Chairman Supervisor: Mohd Roslan Sulaiman, PhD
Divisions: Faculty of Medicine and Health Science
Depositing User: Mohd Nezeri Mohamad
Date Deposited: 18 Jul 2011 03:01
Last Modified: 08 Aug 2011 04:50
URI: http://psasir.upm.edu.my/id/eprint/11247
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