Mechanisms and outcomes of metabolic surgery in type 2 diabetes

Citation

Mansor, Fazliana and Nor Hanipah, Zubaidah (2022) Mechanisms and outcomes of metabolic surgery in type 2 diabetes. Metabolites, 12 (11). art. no. 1134. pp. 1-5. ISSN 2218-1989

Abstract

This review is aimed at synthesizing the mechanisms and outcomes of metabolic surgery on the endocrine system, microbiome, metabolomics, and at the molecular level. We review the hormonal, adipokine, microbiota, microRNA, and metabolomic changes in human and animal models following metabolic surgery for the treatment of obesity and diabetes. The most relevant studies in this area over the past 17 years have been considered for this review. In most cases, metabolic procedures, especially those that include intestinal bypass components, showed the remission of type 2 diabetes. This involves a variety of weight-independent mechanisms to improve glucose homeostasis, improving insulin sensitivity and secretion, gut microbiota, and bile acid cross-talk.

Download File

Full text not available from this repository.

Official URL or Download Paper: https://www.mdpi.com/2218-1989/12/11/1134

Additional Metadata

Item Type:	Article
Divisions:	Faculty of Medicine and Health Science
DOI Number:	https://doi.org/10.3390/metabo12111134
Publisher:	MDPI AG
Keywords:	Diabetes; Bariatric surgery; Metabolic surgery; Endocrine; MicroRNA; Gut microbiota; Metabolomics
Depositing User:	Ms. Che Wa Zakaria
Date Deposited:	08 Jun 2023 02:39
Last Modified:	08 Jun 2023 02:39
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/metabo12111134
URI:	http://psasir.upm.edu.my/id/eprint/102161
Statistic Details:	View Download Statistic

Actions (login required)

View Item