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Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry


Lee, Siew Siew and Ling, King Hwa and Tusimin, Maiza and Subramaniam, Raman and Rahim, Kartini Farah and Loh, Su Peng (2022) Interplay between maternal and neonatal vitamin D deficiency and vitamin-D-related gene polymorphism with neonatal Birth anthropometry. Nutrients, 14 (3). art. no. 564. pp. 1-13. ISSN 2072-6643


Vitamin D deficiency during pregnancy has been associated with poor foetal growth and neonatal birth anthropometry. However, the associations were inconsistent and could be confounded by neonatal vitamin D status and genetic factors. Until recently, limited studies have concomitantly examined the effect of maternal and neonatal vitamin D deficiency and vitamin D-related single nucleotide polymorphisms (SNPs) on neonatal birth anthropometry. This study aims to examine the independent and combined effects of maternal and neonatal vitamin D deficiency and vitamin-D-related SNPs on neonatal birth anthropometry. This cross-sectional study included 217 mother–neonate dyads recruited from Hospital Serdang, Selangor, Malaysia, between 2015 and 2017. Plasma 25-hydroxyvitamin D (25OHD) concentration was measured in maternal and umbilical cord blood using ultra-high-performance liquid chromatography (UHPLC). Maternal and neonatal vitamin D Receptor (VDR) SNP (rs2228570) genotypes were determined using high-resolution melting (HRM). Group-specific component (GC) SNPs (rs4588 and rs7041) genotypes were determined using restriction fragment length polymorphism. Our results showed that: (1) maternal vitamin D deficiency (25OHD < 30 nmol/L) was inversely associated with birth weight, head circumference and crown–heel length; (2) neonatal SNPs, VDR rs2228570 and GC rs4588, were significantly associated with birth weight and head circumference, respectively; and (3) a potential interaction was observed between maternal VDR rs2228570 with maternal vitamin D deficiency on head circumference. These findings suggest that the underlying mechanisms of vitamin D on foetal growth are likely to be localised in the maternal compartment, mediated through the placenta, rather than through cellular mechanisms within the foetus. Further large-scale studies are warranted to validate and extend these findings.

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Official URL or Download Paper: https://www.mdpi.com/2072-6643/14/3/564

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.3390/nu14030564
Publisher: Multidisciplinary Digital Publishing Institute
Keywords: Vitamin D deficiency; Single nucleotide polymorphism; Birth weight; Head circumference; Crown–heel length
Depositing User: Ms. Che Wa Zakaria
Date Deposited: 16 Jun 2023 20:15
Last Modified: 16 Jun 2023 20:15
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/nu14030564
URI: http://psasir.upm.edu.my/id/eprint/101966
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