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Human leucocyte antigens profiling in Malay female patients with systemic lupus erythematosus: are we the same or different


Selvaraja, Malarvili and Too, Chun Lai and Tan, Lay Kim and Koay, Bee Tee and Abdullah, Maha and Md Shah, Anim and Arip, Masita and Amin Nordin, Syafinaz (2022) Human leucocyte antigens profiling in Malay female patients with systemic lupus erythematosus: are we the same or different. Lupus Science and Medicine, 9 (1). pp. 1-14. ISSN 2053-8790


Objective SLE is a heterogeneous autoimmune disease, in terms of clinical presentation, incidence and severity across diverse ethnic populations. We investigated the human leucocyte antigens (HLA) profile (ie, HLA-A, HLA-B and HLA-C, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1 and HLA-DPB1) in Malaysian Malay female patients with SLE and determined the generalisability of the published HLA risk factors across different ethnic populations globally including Malaysia. Methods One hundred Malay female patients with SLE were recruited between January 2016 and October 2017 from a nephrology clinic. All patients were genotyped for HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1 and HLA-DPB1 alleles using PCR sequence-specific oligonucleotides method on Luminex platform. A total of 951 HLA genotyped population-based Malay control subjects was used for association testing by means of OR with 95% CIs. Results Our findings convincingly validated common associations between HLA-A∗11 (OR=1.65, p=3.36×10 -3, corrected P (Pc)=4.03×10 -2) and DQB1∗05:01 (OR=1.56, p=2.02×10 -2, Pc=non-significant) and SLE susceptibility in the Malay population. In contrast, DQB1∗03:01 (OR=0.51, p=4.06×10 -4, Pc=6.50×10 -3) were associated with decreased risk of SLE in Malay population. Additionally, we also detected novel associations of susceptibility HLA genes (ie, HLA-B∗38:02, DPA1∗02:02, DPB1∗14:01) and protective HLA genes (ie, DPA1∗01:03). When comparing the current data with data from previously published studies from Caucasian, African and Asian populations, DRB1∗15 alleles, DQB1∗03:01 and DQA1∗01:02 were corroborated as universal susceptibility and protective genes. Conclusions This study reveals multiple HLA alleles associated with susceptibility and protection against risk of developing SLE in Malay female population with renal disorders. In addition, the published data from different ethnic populations together with our study further support the notion that the genetic effects from association with DRB1∗15:01/02, DQB1∗03:01 and DQA1∗01:02 alleles are generalised to multiple ethnic populations of Caucasian, African and Asian descents.

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Official URL or Download Paper: https://lupus.bmj.com/content/9/1/e000554

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1136/lupus-2021-000554
Publisher: BMJ Publishing Group
Keywords: Autoimmune diseases; Genetic; Polymorphism; Systemic lupus erythematosus
Depositing User: Ms. Che Wa Zakaria
Date Deposited: 08 Nov 2023 08:04
Last Modified: 08 Nov 2023 08:04
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1136/lupus-2021-000554
URI: http://psasir.upm.edu.my/id/eprint/101739
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