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Graphene oxide (GO): a promising nanomaterial against infectious diseases caused by multi-drug resistant organisms


Ng, Ida M. J. and Shamsi, Suhaili (2022) Graphene oxide (GO): a promising nanomaterial against infectious diseases caused by multi-drug resistant organisms. International Journal of Molecular Sciences, 23 (16). art. no. 9096. pp. 1-18. ISSN 1661-6596; ESSN: 1422-0067


Infectious diseases are major threat due to it being the main cause of enormous morbidity and mortality in the world. Multidrug-resistant (MDR) bacteria put an additional burden of infection leading to inferior treatment by the antibiotics of the latest generations. The emergence and spread of MDR bacteria (so-called “superbugs”), due to mutations in the bacteria and overuse of antibiotics, should be considered a serious concern. Recently, the rapid advancement of nanoscience and nanotechnology has produced several antimicrobial nanoparticles. It has been suggested that nanoparticles rely on very different mechanisms of antibacterial activity when compared to antibiotics. Graphene-based nanomaterials are fast emerging as “two-dimensional wonder materials” due to their unique structure and excellent mechanical, optical and electrical properties and have been exploited in electronics and other fields. Emerging trends show that their exceptional properties can be exploited for biomedical applications, especially in drug delivery and tissue engineering. Moreover, graphene derivatives were found to have in vitro antibacterial properties. In the recent years, there have been many studies demonstrating the antibacterial effects of GO on various types of bacteria. In this review article, we will be focusing on the aforementioned studies, focusing on the mechanisms, difference between the studies, limitations and future directions.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
DOI Number: https://doi.org/10.3390/ijms23169096
Publisher: Multidisciplinary Digital Publishing Institute
Keywords: Graphene oxide; Infectious disease; Antibacterial; Multidrug-resistant; Mechanism of action
Depositing User: Ms. Che Wa Zakaria
Date Deposited: 15 Jun 2023 21:20
Last Modified: 15 Jun 2023 21:20
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/ijms23169096
URI: http://psasir.upm.edu.my/id/eprint/101652
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