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Correlation of the GC-MS-based metabolite profile of Momordica charantia fruit and its antioxidant activity


Citation

V., Perumal and A., Khatib and Q. U., Ahmed and B. F., Uzir and F, Abas and S., Murugesu and M. Z., Saiman and R., Primaharinastiti and H., El-Seedi (2022) Correlation of the GC-MS-based metabolite profile of Momordica charantia fruit and its antioxidant activity. International Food Research Journal, 29 (1). art. no. 7. 58 - 66. ISSN 2231-7546

Abstract

Momordica charantia or bitter melon (Cucurbitaceae) is a widely consumed edible fruit with strong antioxidant properties. Due to these properties, it has been commercialised by the natural product industries as a coadjutant in the treatment of various ailments attributable to the deleterious effects of oxidants. The present work aimed to evaluate the antioxidant activity of M. charantia fruit extracts made with different compositions of ethanol:water, and to identify the metabolites that are responsible for this activity. To this end, the fruit samples were extracted using six different concentrations of ethanol in water (0, 20, 40, 60, 80, and 100%). Gas chromatography-mass spectrometry (GC-MS) and multivariate data analysis (MVDA) were used to identify significant antioxidants. The 80% ethanol:water extract showed the most significant (p < 0.05) antioxidant activity when tested with the 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) antioxidant assays. The multivariate data analysis revealed that the metabolites related to this antioxidant activity were gentiobiose, glucose, galactonic acid, palmitic acid, galactose, mannose, and fructose.


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Additional Metadata

Item Type: Article
Divisions: Institute of Bioscience
Institute of Tropical Agriculture and Food Security
DOI Number: https://doi.org/10.47836/ifrj.29.1.07
Publisher: UPM Press
Keywords: Antioxidants; DPPH; FRAP; Metabolomics; Momordica charantia
Depositing User: Ms. Nur Faseha Mohd Kadim
Date Deposited: 17 Aug 2023 07:32
Last Modified: 17 Aug 2023 07:32
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&amp;doi=10.47836/ifrj.29.1.07
URI: http://psasir.upm.edu.my/id/eprint/100817
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