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Clinical and laboratory observation on immunoglobulin replacement therapy switching from an intravenous to a subcutaneous route in a Malaysian X-linked agammaglobulinemia patient


Citation

Ali, Adli and Abdul Wahab, Asrul and Abdul Latiff, Amir Hamzah and Ismail, Intan Hakimah and Mohd Zaki, Faizah and Borhanuddin, Boekhren Karyostyko and Mohd Noh, Lokman (2022) Clinical and laboratory observation on immunoglobulin replacement therapy switching from an intravenous to a subcutaneous route in a Malaysian X-linked agammaglobulinemia patient. Medical Journal of Malaysia, 77 (1). 95 - 97. ISSN 0300-5283

Abstract

We report a clinical and laboratory observation in a boy with X-linked agammaglobulinemia (XLA) who underwent an immunoglobulin replacement therapy (IRT) via the subcutaneous route (IGSC) seven years after his IRT via intravenous route (IGIV). He was free of invasive infections when on IGIV but not the troublesome coughs a week before the next infusion. A switch to a subcutaneous route resulted in significant improvement of symptoms with good weight gain. When on 2-weekly IGSC cycle, adjusting dose for weight resulted in an IgG trough level of > 600 mg/dl.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Malaysian Medical Association
Keywords: X-linked agammaglobulinemia; Immunoglobulin replacement therapy; Malaysia
Depositing User: Ms. Nur Faseha Mohd Kadim
Date Deposited: 15 Sep 2023 07:56
Last Modified: 15 Sep 2023 07:56
URI: http://psasir.upm.edu.my/id/eprint/100706
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