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The Effects of Dexamethasone on the Response of Bronchus-associated Lymphoid Tissue to Intranasal Administration of Formalin-killed Pasteurella haemolytica A2 in Goats


Citation

Saad, Mohd Zamri and Abdul Wahid, Mohd Effendy (1999) The Effects of Dexamethasone on the Response of Bronchus-associated Lymphoid Tissue to Intranasal Administration of Formalin-killed Pasteurella haemolytica A2 in Goats. Veterinary Research Communications, 23 (8). pp. 467-473. ISSN 1573-7446

Abstract / Synopsis

A trial was conducted to observe the immediate and chronic e¡ects in goats of dexamethasone administration on the bronchus-associated lymphoid tissue (BALT) response to intranasal administra- tion of formalin-killed Pasteurella haemolytica A2. Twenty-four goats were divided into four groups. Those in group 1 were injected intramuscularly with 1 mg/kg dexamethasone on three consecutive days, followed by intranasal exposure to formalin-killed P. haemolytica A2 one day after the last dexamethasone treatment. The goats in group 2 were similarly injected with dexamethasone followed by intranasal exposure to formalin-killed P. haemolytica A2 21 days after the last dexamethasone treatment. The animals in group 3 were exposed intranasally to formalin-killed P. haemolytica A2 without prior dexamethasone treatment. The animals in group 4 were untreated controls. The intranasal exposures to formalin-killed P. haemolytica A2 were repeated 2 weeks later. Intranasal exposure to formalin-killed P. haemolytica 1 day after dexamethasone treatment further reduced the number and size of BALT compared to the untreated control. Signi¢cantly (p50.01) more reduction of BALT occurred in goats exposed to formalin-killed P. haemolytica A2 21 days after dexamethasone treatment. On the other hand, intranasal exposure of goats without prior dexamethasone treatment stimulated the BALT compared to the untreated controls.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
DOI Number: 10.1023/A:1006371821128
Publisher: Elsevier Science Publishers
Keywords: BALT, bronchus, dexamethasone, goat, IgA, lymphocytes, Pasteurella haemolytica A2, pneumonia
Depositing User: Azizan Arshad
Date Deposited: 17 Feb 2011 14:35
Last Modified: 17 Feb 2011 14:39
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1023/A:1006371821128
URI: http://psasir.upm.edu.my/id/eprint/9567
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