The Effects of Dexamethasone on the Response of Bronchus-associated Lymphoid Tissue to Intranasal Administration of Formalin-killed Pasteurella haemolytica A2 in Goats

Saad, Mohd Zamri and Abdul Wahid, Mohd Effendy (1999) The Effects of Dexamethasone on the Response of Bronchus-associated Lymphoid Tissue to Intranasal Administration of Formalin-killed Pasteurella haemolytica A2 in Goats. Veterinary Research Communications, 23 (8). pp. 467-473. ISSN 1573-7446

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Abstract

A trial was conducted to observe the immediate and chronic e¡ects in goats of dexamethasone administration on the bronchus-associated lymphoid tissue (BALT) response to intranasal administra- tion of formalin-killed Pasteurella haemolytica A2. Twenty-four goats were divided into four groups. Those in group 1 were injected intramuscularly with 1 mg/kg dexamethasone on three consecutive days, followed by intranasal exposure to formalin-killed P. haemolytica A2 one day after the last dexamethasone treatment. The goats in group 2 were similarly injected with dexamethasone followed by intranasal exposure to formalin-killed P. haemolytica A2 21 days after the last dexamethasone treatment. The animals in group 3 were exposed intranasally to formalin-killed P. haemolytica A2 without prior dexamethasone treatment. The animals in group 4 were untreated controls. The intranasal exposures to formalin-killed P. haemolytica A2 were repeated 2 weeks later. Intranasal exposure to formalin-killed P. haemolytica 1 day after dexamethasone treatment further reduced the number and size of BALT compared to the untreated control. Signi¢cantly (p50.01) more reduction of BALT occurred in goats exposed to formalin-killed P. haemolytica A2 21 days after dexamethasone treatment. On the other hand, intranasal exposure of goats without prior dexamethasone treatment stimulated the BALT compared to the untreated controls.

Item Type:Article
Keyword:BALT, bronchus, dexamethasone, goat, IgA, lymphocytes, Pasteurella haemolytica A2, pneumonia
Faculty or Institute:Faculty of Veterinary Medicine
Publisher:Elsevier Science Publishers
DOI Number:10.1023/A:1006371821128
ID Code:9567
Deposited By: Azizan Arshad
Deposited On:17 Feb 2011 06:35
Last Modified:17 Feb 2011 06:39

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