Characterization of the inclusion complex of zerumbone with hydroxypropyl--cyclodextrin

E. M. Eid, Eltayeb and Abdul, Ahmad Bustamam and O. Suliman, Fakhr Eldin and Sukari, Mohd Aspollah and Abdullah, Rasedee and S. Fatah, Safa (2011) Characterization of the inclusion complex of zerumbone with hydroxypropyl--cyclodextrin. Carbohydrate Polymers, 83 (4). pp. 1707-1714. ISSN 0144-8617

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Official URL: http://dx.doi.org/10.1016/j.carbpol.2010.10.033

Abstract

In this paper we investigated the inclusion complexation between zerumbone (ZER) and hydroxylpropyl- -cyclodextrin (HPCD) at four different temperatures: 293–318 ◦K. The thermodynamic parameters (H, S and G) for the formation of the complex were obtained from the van’t Hoff equation. The complex with HPCD was characterized by differential scanning calorimetry (DSC), X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FT-IR), and molecular modeling using PM6. The solubility of ZER was enhanced >30 fold after complexation. Calculations show that ZER penetrates completely into the cavity of HPCD. The complex retained its cytotoxic activity as shown by in vitro cell survival assay on human cervical cancer (Hela), breast cancer (MCF7 and MDA-MB 231) and human leukemic (CEMss) cell lines. HPCD is, therefore, a suitable encapsular capable of forming thermodynamically stable complex with ZER for save delivery of the compound as an anticancer drug in the future.

Item Type:Article
Keyword:Zerumbone, Hydroxypropyl--cycoldextrin, Cytotoxicity Molecular modeling, PM6,
Faculty or Institute:Faculty of Veterinary Medicine
Publisher:2010 Elsevier Ltd. All rights reserved
DOI Number:10.1016/j.carbpol.2010.10.033
ID Code:9460
Deposited By: Azizan Arshad
Deposited On:08 Feb 2011 04:53
Last Modified:08 Feb 2011 04:55

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