Characterization of the inclusion complex of zerumbone with hydroxypropyl--cyclodextrin

E. M. Eid, Eltayeb and Abdul, Ahmad Bustamam and O. Suliman, Fakhr Eldin and Sukari, Mohd Aspollah and Abdullah, Rasedee and S. Fatah, Safa (2011) Characterization of the inclusion complex of zerumbone with hydroxypropyl--cyclodextrin. Carbohydrate Polymers, 83 (4). pp. 1707-1714. ISSN 0144-8617

Full text not available from this repository.

Official URL:


In this paper we investigated the inclusion complexation between zerumbone (ZER) and hydroxylpropyl- -cyclodextrin (HPCD) at four different temperatures: 293–318 ◦K. The thermodynamic parameters (H, S and G) for the formation of the complex were obtained from the van’t Hoff equation. The complex with HPCD was characterized by differential scanning calorimetry (DSC), X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FT-IR), and molecular modeling using PM6. The solubility of ZER was enhanced >30 fold after complexation. Calculations show that ZER penetrates completely into the cavity of HPCD. The complex retained its cytotoxic activity as shown by in vitro cell survival assay on human cervical cancer (Hela), breast cancer (MCF7 and MDA-MB 231) and human leukemic (CEMss) cell lines. HPCD is, therefore, a suitable encapsular capable of forming thermodynamically stable complex with ZER for save delivery of the compound as an anticancer drug in the future.

Item Type:Article
Keyword:Zerumbone, Hydroxypropyl--cycoldextrin, Cytotoxicity Molecular modeling, PM6,
Faculty or Institute:Faculty of Veterinary Medicine
Publisher:2010 Elsevier Ltd. All rights reserved
DOI Number:10.1016/j.carbpol.2010.10.033
ID Code:9460
Deposited By: Azizan Arshad
Deposited On:08 Feb 2011 04:53
Last Modified:08 Feb 2011 04:55

Repository Staff Only: Edit item detail

Document Download Statistics

This item has been downloaded for since 08 Feb 2011 04:53.

View statistics for "Characterization of the inclusion complex of zerumbone with hydroxypropyl--cyclodextrin"

Universiti Putra Malaysia Institutional Repository

Universiti Putra Malaysia Institutional Repository is an on-line digital archive that serves as a central collection and storage of scientific information and research at the Universiti Putra Malaysia.

Currently, the collections deposited in the IR consists of Master and PhD theses, Master and PhD Project Report, Journal Articles, Journal Bulletins, Conference Papers, UPM News, Newspaper Cuttings, Patents and Inaugural Lectures.

As the policy of the university does not permit users to view thesis in full text, access is only given to the first 24 pages only.