Studies on coordination chemistry and bioactivity of complexes of Ni(II) and Cu(II) containing some nitrogen-sulphur donor ligands

Nagalingam, Saravanan (2001) Studies on coordination chemistry and bioactivity of complexes of Ni(II) and Cu(II) containing some nitrogen-sulphur donor ligands. Masters thesis, Universiti Pertanian Malaysia.

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Abstract

Several Schiff bases of S-benzyldithiocarbazate (SBDTC) and Smethyldithiocarbazate (SMDTC) have been synthesised. Complexes of NiCll) and Cu(IT) were prepared. These compounds were characterised by elemental analyses and various physico-chemical techniques. The Schiff bases and their metal complexes were tested to evaluate their cytotoxic, antimicrobial and antioxidant activities. Cytotoxic screening was carried out against the T-Iymphoblastic leukemic cells (CEM-SS) and colon cancer cells (HT-29). Antimicrobial screening was carried out against four bacteria and four fungi. The nickelCTI) complexes are four- and five- coordinated while the copper(TI) complex is five-coordinated.

Item Type:Thesis (Masters)
Subject:Schiff bases - Synthesis
Chairman Supervisor:Associate Professor Dr. Md. Tofazzal Hossain Tarafder
Call Number:FSAS 2001 37
Faculty or Institute:Faculty of Environmental Studies
ID Code:9300
Deposited By: Tuan Norasiah Tuan Yaacob
Deposited On:19 Jan 2011 04:51
Last Modified:15 May 2012 04:20

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