Effect of Phenobarbitone Treatment Against Signal Grass (Brachiaria decumbens) Toxicity in Sheep

Ab. Hamid, Hasiah and H. A., ElSheikh and Abdullah, Abdul Salam and Hussain, Mohd Khairi and Rajion, Mohamed Ali (2000) Effect of Phenobarbitone Treatment Against Signal Grass (Brachiaria decumbens) Toxicity in Sheep. The Veterinary Journal, 160 (3). pp. 267-272. ISSN 1090-0233

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Official URL: http://dx.doi.org/10.1053/tvjl.2000.0498


The effect of phenobarbitone against signal grass (Brachiaria decumbens) toxicity was studied in 26 male crossbred sheep. Grazing on signal grass significantly decreased the concentration of cytochrome P-450 and the activity of drug metabolizing enzymes, viz. aminopyrine-N-demethylase, aniline-4-hydroxylase, UDP- glucuronyltransferase and glutathione-S-transferase in liver and kidneys of affected sheep. Oral administration of phenobarbitone (30 mg/kg body weight) for five consecutive days before grazing on B. decumbens pasture, and thereafter, for three consecutive days every two weeks, resulted in significant increases in hepatic and renal activities of drug-metabolizing enzymes. The induction of drug metabolizing activity in sheep grazing on signal grass group was found to be lower than in animals given phenobarbitone alone. Induction by phenobarbitone provided a degree of protection against the toxic effects of B. decumbens as indicated by the delay in the appearance of signs of toxicity. Furthermore, these were much milder compared to those in the sheep not treated with phenobarbitone. The present study suggests that phenobarbitone-type cytochrome P-450 isoenzyme-induction may increase resistance against signal grass (B. decumbens) toxicity in sheep.

Item Type:Article
Keyword:Brachiaria decumbens, drug metabolism, phenobarbitone, sheep, signal grass
Faculty or Institute:Faculty of Veterinary Medicine
Publisher:Elsevier Science
DOI Number:10.1053/tvjl.2000.0498
ID Code:7861
Deposited By: Azizan Arshad
Deposited On:27 Sep 2010 06:26
Last Modified:27 Sep 2010 06:38

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