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Diagnostic Methods for Feline Coronavirus: A Review


Citation

Sharif, Saeed and Arshad, Siti Suri and Bejo, Mohd Hair and Omar, Abdul Rahman and Alauddin, Zeenathul Nazariah and Khazal Saleh, Amer Alazawy (2010) Diagnostic Methods for Feline Coronavirus: A Review. Veterinary Medicine International, 2010. pp. 1-7. ISSN 2042-0048

Abstract / Synopsis

Feline coronaviruses (FCoVs) are found throughout the world. Infection with FCoV can result in a diverse range of signs from clinically inapparent infections to a highly fatal disease called feline infectious peritonitis (FIP). FIP is one of the most serious viral diseases of cats. While there is neither an effective vaccine, nor a curative treatment for FIP, a diagnostic protocol for FCoV would greatly assist in the management and control of the virus. Clinical findings in FIP are non-specific and not helpful in making a differential diagnosis. Haematological and biochemical abnormalities in FIP cases are also non-specific. The currently available serological tests have low specificity and sensitivity for detection of active infection and cross-react with FCoV strains of low pathogenicity, the feline enteric coronaviruses (FECV). Reverse transcriptase polymerase chain reaction (RT-PCR) has been used to detect FCoV and is rapid and sensitive, but results must be interpreted in the context of clinical findings. At present, a definitive diagnosis of FIP can be established only by histopathological examination of biopsies. This paper describes and compares diagnostic methods for FCoVs and includes a brief account of the virus biology, epidemiology, and pathogenesis.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
DOI Number: 10.4061/2010/809480
Publisher: SAGE-Hindawi Access to Research
Depositing User: Muizzudin Kaspol
Date Deposited: 18 Aug 2010 09:50
Last Modified: 18 Aug 2010 09:50
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.4061/2010/809480
URI: http://psasir.upm.edu.my/id/eprint/7722
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