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A new cytotoxic carbazole alkaloid from Clausena excavata

Yap, Taufiq Yun Hin and Peh, Tian Hai and Ee, Gwendoline Cheng Lian and Rahmani, Mawardi and Md. Sukari, Mohd Aspollah and Ali, Abdul Manaf and Muse, Radzali (2007) A new cytotoxic carbazole alkaloid from Clausena excavata. Natural Product Research, 21 (9). pp. 810-813. ISSN 1478-6419; ESSN: 1478-6427

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A new carbazole alkaloid, 3-carbomethoxy-2-hydroxy-7-methoxycarbazole, Clausine-TY (1),together with two known carbazole alkaloid, Clausine-H (2) and Clausine-B (3), were isolated from the ethyl acetate extract of the stem bark of the Malaysian Clausena excavata. The structures of these compounds were elucidated by spectroscopic analyses. The new carbazole alkaloid shows significant cytotoxicity against CEM-SS cell line.

Item Type:Article
Keyword:Clausena excavata; Rutaceae; Stem bark; Carbazole alkaloid; Anticancer activity
Faculty or Institute:Faculty of Science
Publisher:Taylor & Francis
DOI Number:10.1080/14786410701258875
ID Code:7660
Deposited By: Najwani Amir Sariffudin
Deposited On:09 Aug 2010 15:44
Last Modified:24 Nov 2016 16:42

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