Ab Shukor, Nor Aini and Merrina, A. and Stanslas, Johnson and Subramaniam, Sreeramanan (2008) Cytotoxic Potential on Breast Cancer Cells Using Selected Forest Species Found in Malaysia. International Journal of Cancer Research, 4 (3). pp. 103-109. ISSN 1097-0215
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In vitro studies were carried out to evaluate the cytotoxic potential of three selected forest herbaceous species: Tectaria singaporeana (TS), Blechnum orientale (BO) and Tacca integrifolia (TCI). Methanol/methylene chloride extracts of three plant parts viz. leaves, roots and stems were assessed for their cytotoxic potential against human breast cancer cells (MCF-7wt.). Screening of these extracts was done using the microculture, followed by tetrazolium assay after a period of 72 h. There were significant differences between different parts of plants and dilution levels in terms of cytotoxicity, with roots and concentration of 100 Î¼g mL-1 showing the highest cell mortality of 19.58 and 36.59%, respectively. However, the leaves and the stems of all three plant species did not induce any cytotoxic activity on the cells. Overall, the most promising material (IC50 <100 Î¼g mL-1) were the methanolic extracts from the roots of all three plants. Tectaria singaporeana showed the highest cytotoxic potential with an IC50 value of 28.57 Â± 11.74 Î¼g mL-1 followed by Blechnum orientale, 32.07 Â± 7.85 Î¼g mL-1 and Tacca integrifolia, 95.03 Â± 17.49 Î¼g mL-1. From this study, the extracts of these plants may prove to be useful in cancer treatment and prevention.
|Keyword:||Medical plants, Apoptosis, Breast Cancer, Tectaria singaporeana, Blechnum orientale, Tacca integrifolia|
|Faculty or Institute:||Faculty of Forestry|
|Deposited By:||Norhazura Hamzah|
|Deposited On:||09 Aug 2010 01:54|
|Last Modified:||09 Aug 2010 02:02|
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