Cytotoxic Potential on Breast Cancer Cells Using Selected Forest Species Found in Malaysia

Ab Shukor, Nor Aini and Merrina, A. and Stanslas, Johnson and Subramaniam, Sreeramanan (2008) Cytotoxic Potential on Breast Cancer Cells Using Selected Forest Species Found in Malaysia. International Journal of Cancer Research, 4 (3). pp. 103-109. ISSN 1097-0215

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In vitro studies were carried out to evaluate the cytotoxic potential of three selected forest herbaceous species: Tectaria singaporeana (TS), Blechnum orientale (BO) and Tacca integrifolia (TCI). Methanol/methylene chloride extracts of three plant parts viz. leaves, roots and stems were assessed for their cytotoxic potential against human breast cancer cells (MCF-7wt.). Screening of these extracts was done using the microculture, followed by tetrazolium assay after a period of 72 h. There were significant differences between different parts of plants and dilution levels in terms of cytotoxicity, with roots and concentration of 100 μg mL-1 showing the highest cell mortality of 19.58 and 36.59%, respectively. However, the leaves and the stems of all three plant species did not induce any cytotoxic activity on the cells. Overall, the most promising material (IC50 <100 μg mL-1) were the methanolic extracts from the roots of all three plants. Tectaria singaporeana showed the highest cytotoxic potential with an IC50 value of 28.57 ± 11.74 μg mL-1 followed by Blechnum orientale, 32.07 ± 7.85 μg mL-1 and Tacca integrifolia, 95.03 ± 17.49 μg mL-1. From this study, the extracts of these plants may prove to be useful in cancer treatment and prevention.

Item Type:Article
Keyword:Medical plants, Apoptosis, Breast Cancer, Tectaria singaporeana, Blechnum orientale, Tacca integrifolia
Faculty or Institute:Faculty of Forestry
ID Code:7641
Deposited By: Norhazura Hamzah
Deposited On:09 Aug 2010 01:54
Last Modified:09 Aug 2010 02:02

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