Zerumbone Exerts Antiproliferative Activity via Apoptosis on HepG2 Cells
Syed Alwi, Sharifah Sakinah, Nallappan, Meenakshii and Lope Pihie, Azimahtol Hawariah (2007) Zerumbone Exerts Antiproliferative Activity via Apoptosis on HepG2 Cells. Malaysian Journal of Biochemistry and Molecular Biology, 15 (1). pp. 19-23. ISSN 1511-2616
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Zerumbone, a cytotoxic component isolated from Zingiber zerumbet Smith, significantly displayed antiproliferative effect towards human cancer cell lines including the human liver cancer HepG2 cell line (IC50 of 3.45 ± 0.026 μg/ml), human breast cancer MCF-7 cell line (IC50 of 3.73 ± 0.085 μg/ml), human ovarian cancer Caov-3 cell line (IC50 of 4.73 ± 0.052 μg/ml) and human cervix cancer HeLa cell line (IC50 of 5.43 ± 0.033 μg/ml). The action of zerumbone appeared to be cytoselective as its effect on the proliferation of non-malignant Chang liver cells generated IC50 value that was much higher than that obtained for all zerumbonetreated cancer cell lines (10.96 ± 0.059 μg/ml). The antiproliferative effect of zerumbone was also shown to occur via apoptosis.The extent of DNA fragmentation, evaluated by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling assay, showed that zerumbone significantly increased apoptosis of the HepG2 cells in a time-course manner and that its effect was generally more potent than cisplatin.
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