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Analysis of essential gene changes in MRSA and non-MRSA strains inhibited by methanolic extract correlated to membrane permeabilising peptide

Shamsudin, M. and Mohamed Alipiah, Norfarrah and Neela, Vasantha Kumari and Md Yusoff, Fatimah and Arshad, Aziz (2007) Analysis of essential gene changes in MRSA and non-MRSA strains inhibited by methanolic extract correlated to membrane permeabilising peptide. International Journal of Antimicrobial Agents, 29 (suppl.2). S634. ISSN 0924-8579

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Official URL: http://dx.doi.org/10.1016/S0924-8579(07)72030-7

Abstract

In this study, a methanolic extract derived from a marine organism was investigated for the effect on the growth of MRSA resistant to b-lactam antibiotics. The nucleotide sequence changes of essential genes inclusive of mecA, mecR1, 16sRNA, mprF and msR of the inhibited MRSA strains were determined. A potential antibacterial peptide with activity on permeabilising the membrane of MRSA strains was investigated through a cellular bioassay.

Item Type:Article
Faculty or Institute:Faculty of Science
Publisher:Elsevier
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/S0924-8579(07)72030-7
ID Code:7269
Deposited By: Najwani Amir Sariffudin
Deposited On:14 Jun 2010 17:18
Last Modified:30 Jul 2010 12:27

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