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Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves.

Khin, Myat Nwe and Saad, Mohd zamri and Mohamed Mustapha, Noordin and Abd Wahid, Mohd Effendy (2009) Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves. Online Journal of Veterinary Research, 13 (2). pp. 64-71. ISSN 1328-925X

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Abstract

This report describes the effect of vaccination with attenuated P. multocida B:2 on wild-type P. multocida B:2 infection in calves. Calves were given 5 ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves were then mingled with the vaccinated Group. Control untreated calves were kept separate. After 6 weeks, all calves were challenged intra-tracheally with 107 CFU/mL of live wild-type P. multocida B:2. At Post-Mortem none of the vaccinated or mingled calves had lesions whereas controls revealed pulmonary petechial haemorrhages with acute pneumonia patches with neutrophils. Both exposed and commingled calves showed significantly (p<0.05) higher levels of serum IgG. P. multocida B:2 were successfully isolated only from the control calves of Group 3. These findings suggest that intranasal exposures to live attenuated P. multocida B:2 prevented infection by wild-type P. multocida B:2 and may have protected susceptible calves.

Item Type:Article
Keyword:Intranasal; Attenuated Pasteurella multocida B:2; Infection.
Faculty or Institute:Faculty of Veterinary Medicine
Publisher:Online Journal of Veterinary Research
ID Code:7064
Deposited By: Azizan Arshad
Deposited On:04 Jun 2010 06:35
Last Modified:20 Nov 2013 04:28

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