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Respiratory macrophage activity and pulmonary morphology following exposure to benzo(a)pyrene in broilers


Citation

Latif, I. K. and Karim, Abdulkarim Jafar and Abu Bakar @ Zakaria, Md Zuki and Saad, Mohd Zamri and Niu, J. P. and Mohamed Mustapha, Noordin (2009) Respiratory macrophage activity and pulmonary morphology following exposure to benzo(a)pyrene in broilers. Online Journal of Veterinary Research, 13 (2). pp. 128-135. ISSN 1328-925X

Abstract / Synopsis

The effect of benzo(a)pyrene (BaP) on the macrophage defense system and lung morphology in broilers was evaluated. One day age chicks were divided into 4 groups of 40. Control chicks were given tricaprylin alone intratracheally (IT), while treated groups were given BaP (viz, at 1.5 micro g, 150 micro g or 15 mg/kg bodyweight) for 5 consecutive days IT. Ten birds per group were sacrificed at days 7, 14, 21 and 35. Respiratory lavage was performed immediately to procure avian respiratory macrophages (ARM). A significant decrease in the mean values of the given lavage volume, phagocytosis and intracellular killing activities along with an increase in ARM counts was observed especially in the group receiving 15 mg BaP, suggesting a possible immunopulmonary toxic effect of inhaled BaP.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
Publisher: Online Journal of Veterinary Research
Keywords: Benzo(a)pyrene; Intra-tracheal; Macrophage; Toxicity; Broiler
Depositing User: Azizan Arshad
Date Deposited: 04 Jun 2010 14:50
Last Modified: 21 Nov 2016 10:11
URI: http://psasir.upm.edu.my/id/eprint/7063
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