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Development of honey hydrogel dressing for enhanced wound healing

Yusof, Norimah and Abdul Hair, Ainul Hafiza and Mohd Zohdi, Rozaini and Abu Bakar Zakaria, Md Zuki (2007) Development of honey hydrogel dressing for enhanced wound healing. Radiation Physics and Chemistry, 76 (11-12). pp. 1767-1770. ISSN 0969-806X

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Official URL: http://dx.doi.org/10.1016/j.radphyschem.2007.02.10...

Abstract

Radiation at 25 and 50 kGy showed no effect on the acidic pH of the local honey, Gelam, and its antimicrobial property against Staphylococcus aureus but significantly reduced the viscosity. Honey stored up to 2 years at room temperature retained all the properties studied. Radiation sterilized Gelam honey significantly stimulated the rate of burn wound healing in Sprague-Dawley rats as demonstrated by the increased rate of wound contraction and gross appearance. Gelam honey attenuates wound inflammation; and re-epithelialization was well advanced compared to the treatment using silver sulphadiazine (SSD) cream. To enhance further the use of honey in wound treatment and for easy handling, Gelam honey was incorporated into our hydrogel dressing formulation, which was then cross-linked and sterilized using electron beam at 25 kGy. Hydrogel with 6% of honey was selected based on the physical appearance.

Item Type:Article
Keyword:Honey, Radiation sterilization, Cross-linking, Hydrogel
Faculty or Institute:Faculty of Veterinary Medicine
Publisher:Elsevier
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.radphyschem.2007.02.107
ID Code:6962
Deposited By: Azizan Arshad
Deposited On:25 May 2010 01:41
Last Modified:01 Jun 2011 05:04

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