Screening of microfilaricidal effects of plant extracts against Dirofilaria immitis

Merawin, Leonora Tuah and Abdul Kadir, Arifah and Abdullah Sani, Rehana and Somchit, Muhammad Nazrul and Ahmad, Zuraini and Ganabadi, Shanti and Zakaria, Zainul Amiruddin (2010) Screening of microfilaricidal effects of plant extracts against Dirofilaria immitis. Research in Veterinary Science, 88 (1). pp. 142-147. ISSN 0034-5288

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Official URL: http://dx.doi.org/10.1016/j.rvsc.2009.05.017

Abstract

Canine dirofilariasis is a common tropical parasitic disease of companion animals, caused by infestation of Dirofilaria immitis filarids within the pulmonary arteries and extending into the right heart. Increased reports of adverse reactions elicited by current microfilaricidal agents against D. immitis such as neurological disorders, circulatory collapse and potential resistance against these agents, warrant the search for new agents in forms of plant extracts. The use of plant extracts in therapeutic medicine is commonly met with scepticism by the veterinary community, thus the lack of focus on its medical potential. This study evaluated the presence of microfilaricidal activities of the aqueous extracts of Zingiber officinale, Andrographis paniculata and Tinospora crispa Miers on D. immitis in vitro at different concentrations; 10 mg/ml,1 mg/ml, 100 lg/ml, 10 lg/ml and 1 lg/ml within 24 h, by evaluation of relative microfilarial motility as a measure of microfilaricidal activity. All extracts showed microfilaricidal activity with Z. officinale exhibiting the strongest activity overall, followed by A. paniculata and T. crispa Miers. It is speculated that the microfilaricidal mechanism exhibited by these extracts is via spastic paralysis based upon direct observation of the microfilarial motility.

Item Type:Article
Keyword:Dirofilaria immitis, Zingiber officinale, Andrographis paniculata, Tinospora crispa Miers
Faculty or Institute:Faculty of Veterinary Medicine
Publisher:Elsevier
DOI Number:10.1016/j.rvsc.2009.05.017
ID Code:6328
Deposited By: Azizan Arshad
Deposited On:13 May 2010 03:27
Last Modified:19 Aug 2010 04:29

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