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Ultrastructural pathology of the upper respiratory tract of rabbits experimentally infected with Pasteurella multocida A:3


Citation

M. H., Al-Haddawi and Sabri, Jasni and Saad , Mohd Zamri and Mutalib, Abdul Rahim and Abdul Rahman, Sheikh Omar (1999) Ultrastructural pathology of the upper respiratory tract of rabbits experimentally infected with Pasteurella multocida A:3. Research in Veterinary Science, 67 (2). pp. 161-168. ISSN 0034-5288

Abstract / Synopsis

Twenty-four 8 to 9 week-old Pasteurella multocida-free rabbits were divided into three equal groups, the first group was pretreated with hydrocortisone and inoculated intranasally with pasteurella multocida serotype A:3. The second group was inoculated intranasally with P. multocida without hydrocortisone treatment. The third group was inoculated with phosphate buffered saline only and used as a control group. Pasteurella multocida was isolated from the nasal cavity of all infected rabbits in group 1 and 2 and from the trachea of seven rabbits in group 1 and five rabbits in group 2. This study was conducted to observe the ultrastructural changes of the upper respiratory tract of hydrocortisone treated and non-treated rabbits infected with P. multocida serotype A:3. The ultrastructural changes detected in infected rabbits were ciliary destruction and deciliation of the ciliated epithelial cells, cellular swelling, goblet cell hyperplasia and endothelial cell damage. Pasteurella multocida was observed attached to the degenerated cilia,microvilli and mucus. Pasteurella multocida infection was associated with inflammatory responses, which may have caused tissue damage. It is possible that hydrocortisone modulates the severity of infection as an immune suppressor and an inhibitor of goblet cell secretion.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
Publisher: 1999 Harcourt Publishers Limited
Depositing User: Azizan Arshad
Date Deposited: 12 May 2010 12:30
Last Modified: 26 Oct 2015 12:14
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1053/rvsc.1998.0299
URI: http://psasir.upm.edu.my/id/eprint/6254
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