Ultrastructural pathology of nasal and tracheal mucosa of rabbits experimentally infected with Pasteurella multocida serotype D:1

Muthaffar Hussain, Al-Haddawi and Sabri, Jasni and Israf Ali, Daud Ahmad and Saad, Mohd Zamri and Mutalib, Abdul Rahim and Abdul Rahman, Sheikh Omar (2001) Ultrastructural pathology of nasal and tracheal mucosa of rabbits experimentally infected with Pasteurella multocida serotype D:1. Research in Veterinary Science, 70 (3). pp. 191-197. ISSN 0034-5288

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Official URL: http://dx.doi.org/10.1053/rvsc.2001.0459


Sixteen 8- to 9-week-old Pasteurella multocida-free New Zealand White rabbits were divided into two equal groups. The first group was inoculated intranasally with P multocida serotype D:1 strain and the second group that was inoculated with phosphate-buffered saline (PBS) only was used as a control group. Pasteurella multocida was isolated from the nasal cavity of all infected rabbits in group 1 and from tracheal swabs of seven rabbits in this group. Four rabbits in group 1 died with clinical signs of septicaemia, two rabbits had mucopurulent nasal discharge and pneumonic lesions and the other two did not show any clinical signs or gross lesions. The ultrastructural changes detected were deciliation or clumping of cilia of ciliated epithelium, cellular swelling, vacuolation and sloughing. The subepithelial capillaries showed congestion, intravascular fibrin deposition, platelets aggregation and endothelial injury. Pasteurella multocida was observed attached to the injured endothelial cells. Heterophils, mast cells, vacuolated monocytes and macrophages infiltrated the lamina propria and between the degenerated epithelial cells. ©2001 Harcourt Publishers Ltd

Item Type:Article
Faculty or Institute:Faculty of Veterinary Medicine
Publisher:Harcourt Publishers Limited
DOI Number:10.1053/rvsc.2001.0459
ID Code:6251
Deposited By: Azizan Arshad
Deposited On:12 May 2010 04:44
Last Modified:19 Aug 2010 07:44

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