Obesity and Risk of Colorectal Adenomatous Polyps: a Case-Control Study in Hospital Kuala Lumpur

Ramadas, Amutha and Hambali, Zarida and Alif Gul, Yunus Gul and Jabal, Mohd Faizal and Kandiah, Marlini (2009) Obesity and Risk of Colorectal Adenomatous Polyps: a Case-Control Study in Hospital Kuala Lumpur. Malaysian Journal of Nutrition, 15 (1). pp. 2-10. ISSN 1394-035X

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Colorectal adenomas are precursor lesions of colorectal cancer. Several studies have proposed that obesity is a risk factor for colorectal adenoma. This case-control study examined the relationship between body mass index (BMI), waist circumference, waistto-hip ratio (WHR), body fat percentage and colorectal adenomatous polyps (CRA) in patients who have had a colonoscopy at the Hospital Kuala Lumpur (HKL). Fifty-nine patients (42 males and 17 females) positively identified as having CRA and 59 polypfree subjects were recruited as controls (33 males and 26 females). A pre-tested questionnaire was used to collect socio-economic information, while anthropometric measurements were determined directly by established methods. The mean BMI of female case subjects was significantly higher than control females (25.63 + 4.87 kg/m2 vs. 23.86 + 3.70 kg/m2, p<0.05) but the difference in BMI was not significant in men. The mean WHR of male subjects was significantly higher in the case group (0.92 + 0.07 vs. 0.90 + 0.06, p<0.05). After adjusting for confounders, waist circumference was the only indicator that was found to significantly increase the risk for CRA in women (OR = 6.349, 95% CI = 1.063 � 37.919). Higher BMI, WHR and body fat percentage showed a non-significant risk in female subjects. In men, none of the obesity indicators were found to be significant risk factors for CRA. These findings suggest that abdominal obesity may be a contributing factor to CRA risk particularly in women. A prospective study is needed to confirm the role of obesity in the development of CRA in Malaysians. A1, Kandiah M2, H3, & JA4

Item Type:Article
Faculty or Institute:Faculty of Medicine and Health Science
Publisher:Nutrition Society of Malaysia
ID Code:6189
Deposited By: Norhaznita Mahmood
Deposited On:12 May 2010 06:46
Last Modified:27 May 2013 07:27

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