Simple Search:

Sequence and phylogenetic analysis of Newcastle disease virus genotypes isolated in Malaysia between 2004 and 2005


Citation

Tan, Sheau Wei and Ideris, Aini and Omar, Abdul Rahman and Bejo, Mohd Hair (2009) Sequence and phylogenetic analysis of Newcastle disease virus genotypes isolated in Malaysia between 2004 and 2005. Archives of Virology, 155 (1). pp. 63-70. ISSN 0304-8608

Abstract / Synopsis

Sequence analysis of the fusion (F) gene of eight Malaysian NDV isolates showed that all the isolates were categorized as velogenic viruses, with the F cleavage site motif 112R-R-Q-K-R116 or 112R-R-R-K-R116 at the C-terminus of the F2 protein and phenylalanine (F) at residue 117 at the N-terminus of the F1 protein. Phylogenetic analysis revealed that all of the isolates were grouped in two distinct clusters under sub-genotype VIId. The isolates were about 4.8–11.7% genetically distant from sub-genotypes VIIa, VIIb, VIIc and VIIe. When the nucleotide sequences of the eight Malaysian isolates were compared phylogenetically to those of the old published local isolates, it was found that genotype VIII, VII, II and I viruses exist in Malaysia and caused sporadic infections. It is suggested that genotype VII viruses were responsible for most of the outbreaks in recent years.


Download File

[img]
Preview
PDF (Abstract)
Sequence and phylogenetic analysis of Newcastle disease virus genotypes isolated in Malaysia between 2004 and 2005.pdf

Download (148kB) | Preview

Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
DOI Number: 10.1007/s00705-009-0540-4
Publisher: Springer Wien
Depositing User: Azizan Arshad
Date Deposited: 10 May 2010 16:23
Last Modified: 19 Jan 2016 11:16
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s00705-009-0540-4
URI: http://psasir.upm.edu.my/id/eprint/6139
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item