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Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study

Md Ajat, Mohd Mokrish, Yusoff, Khatijah and Hussein, Mohd Zobir (2008) Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study. Current Nanoscience, 4 (4). pp. 391-396. ISSN 1573-4137

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Official URL: http://dx.doi.org/10.2174/157341308786306161

Abstract

A layered compound of zinc-aluminium layered double hydroxide (LDH) to be used as a host for a guest amino acid, glutamate was synthesized. Different parameters were used and optimized to form amino acid-intercalated pure phase materials. The resulting Bio-Inorganic Nanohybrid (BINH) was chosen for further characterization. BINH exhibits the glutamate to be in vertical or perpendicular orientation to the inorganic layer. Cytotoxicty test indicates that the IC50 value was observed at 3.125 μg/ml. Results from this study will be used in the development of a new delivery system for therapeutic agents comprising amino acids or peptides.

Item Type:Article
Keyword:Nanobiotechnology, glutamate, layered double hydroxide, bio-inorganic nanohybrid
Faculty or Institute:Faculty of Science
Publisher:Bentham Science Publishers
DOI Number:10.2174/157341308786306161
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.2174/157341308786306161
ID Code:5821
Deposited By: Najwani Amir Sariffudin
Deposited On:04 May 2010 08:02
Last Modified:30 Jul 2010 04:22

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