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Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study

Md Ajat, Mohd Mokrish and Yusoff, Khatijah and Hussein, Mohd Zobir (2008) Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study. Current Nanoscience, 4 (4). pp. 391-396. ISSN 1573-4137

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Abstract / Synopsis

A layered compound of zinc-aluminium layered double hydroxide (LDH) to be used as a host for a guest amino acid, glutamate was synthesized. Different parameters were used and optimized to form amino acid-intercalated pure phase materials. The resulting Bio-Inorganic Nanohybrid (BINH) was chosen for further characterization. BINH exhibits the glutamate to be in vertical or perpendicular orientation to the inorganic layer. Cytotoxicty test indicates that the IC50 value was observed at 3.125 μg/ml. Results from this study will be used in the development of a new delivery system for therapeutic agents comprising amino acids or peptides.

Item Type: Article
Divisions: Faculty of Science
DOI Number: 10.2174/157341308786306161
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.2174/157341308786306161
Publisher: Bentham Science Publishers
Keywords: Nanobiotechnology, glutamate, layered double hydroxide, bio-inorganic nanohybrid
Depositing User: Najwani Amir Sariffudin
Date Deposited: 04 May 2010 16:02
Last Modified: 26 Oct 2015 08:56
URI: http://psasir.upm.edu.my/id/eprint/5821

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