Synthesis, characterization and biological studies of S- benzyl-b-N-(benzoyl)dithiocarbazate and its metal complexes

How, Fiona Ni Foong and Crouse, Karen Anne and Mohamed Tahir, Mohamed Ibrahim and Tarafder, Md. Tofassa Hossain and Cowley, Andrew R. (2008) Synthesis, characterization and biological studies of S- benzyl-b-N-(benzoyl)dithiocarbazate and its metal complexes. Polyhedron, 27 (15). pp. 3325-3329. ISSN 0277-5387

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Official URL: http://dx.doi.org/10.1016/j.poly.2008.07.022

Abstract

S-Benzyl-b-N-(benzoyl) dithiocarbazate (SBNBODTC) a new disubstituted dithio-carbazate oxygen–sulfur (OS) donor ligand derived from reaction of S-benzyl dithiocarbazate with benzoyl chloride, formed bischelated complexes of general formula [M(OS)2] where M is Cu2+, Ni2+, Cd2+, Co2+ or Pb2+ and OS is a uninegative bidentate ligand. The ligand and its metal complexes have been characterized by a variety of physico-chemical techniques. S-benzyl-b-N-(benzoyl) dithiocarbazate crystallized with Z0 = 2 in its thione form in cis–cis conformation, with the N–N bond adopting a cis geometry with respect to C@S, while the S-benzyl group adopts a cis geometry with respect to the thione sulfur atom across the C–S bond.SBNBODTC, Cu(OS)2, Ni(OS)2 and Pb(OS)2 display marked cytotoxicity against HL-60 (human myeloid leukemia)while Cd(OS)2 and Co(OS)2 are moderately cytotoxic. The compounds showed moderate but selective activity towards targeted pathogens.

Item Type:Article
Keyword:Dithiocarbazate, Metal complex, Bidentate ligand, Bis-chelated
Faculty or Institute:Faculty of Science
Publisher:Elsevier
DOI Number:10.1016/j.poly.2008.07.022
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.poly.2008.07.022
ID Code:5690
Deposited By: Najwani Amir Sariffudin
Deposited On:30 Apr 2010 03:51
Last Modified:22 Jul 2010 14:57

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