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Evaluation of the Insulinotrophic Activity of Malaysian Traditional Plants Extract


Citation

Hamid, Muhajir and Mohd Bohari, Siti Pauliena and Bastami, Mohd Saufi and Ali, Abdul Manaf and Mustapha, Nik Musa'adah and Shari, Khozirah (2008) Evaluation of the Insulinotrophic Activity of Malaysian Traditional Plants Extract. Journal of Biological Sciences, 8 (1). pp. 201-204. ISSN 1727-3048

Abstract / Synopsis

In this study, methanolic extracts of 14 traditional plants in Malaysia were screened for insulinotrophic properties, using rat pancreatic B-cell lines, BRIN-BD11 cells. In 30min acute static incubation test, all 14 plants showed varying degree of responsivess in insulin release with Labisa pumila, Morinda charantia and Tinospora crispa having high insulinotrophic activities. These plants also displayed appreciably low cyotoxic activities. These results show a promising avenue for development of novel insulin secretagogues.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
DOI Number: 10.3923/jbs.2008.201.204
Publisher: Asian Network for Scientific Information
Keywords: Insulinotrophic, malaysian traditional plants, rat pancreatic B-cell lines
Depositing User: Najwani Amir Sariffudin
Date Deposited: 30 Apr 2010 12:26
Last Modified: 17 Sep 2015 08:59
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3923/jbs.2008.201.204
URI: http://psasir.upm.edu.my/id/eprint/5664
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