Evaluation of the Insulinotrophic Activity of Malaysian Traditional Plants Extract

Hamid, Muhajir and Mohd Bohari, Siti Pauliena and Bastami, Mohd Saufi and Ali, Abdul Manaf and Mustapha, Nik Musa'adah and Shari, Khozirah (2008) Evaluation of the Insulinotrophic Activity of Malaysian Traditional Plants Extract. Journal of Biological Sciences, 8 (1). pp. 201-204. ISSN 1727-3048

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Official URL: http://dx.doi.org/10.3923/jbs.2008.201.204


In this study, methanolic extracts of 14 traditional plants in Malaysia were screened for insulinotrophic properties, using rat pancreatic B-cell lines, BRIN-BD11 cells. In 30min acute static incubation test, all 14 plants showed varying degree of responsivess in insulin release with Labisa pumila, Morinda charantia and Tinospora crispa having high insulinotrophic activities. These plants also displayed appreciably low cyotoxic activities. These results show a promising avenue for development of novel insulin secretagogues.

Item Type:Article
Keyword:Insulinotrophic, malaysian traditional plants, rat pancreatic B-cell lines
Faculty or Institute:Faculty of Science
Publisher:Asian Network for Scientific Information
DOI Number:10.3923/jbs.2008.201.204
ID Code:5664
Deposited By: Najwani Amir Sariffudin
Deposited On:30 Apr 2010 04:26
Last Modified:29 Sep 2010 07:28

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