Protective effect following intranasal exposure of goats to live Pasteurella multocida B:2

Saad, Mohd Zamri and Ali, Ernie Zuraida and Mohd Yusoff, Md Sabri (2006) Protective effect following intranasal exposure of goats to live Pasteurella multocida B:2. Tropical Animal Health Production, 38 (7-8). pp. 541-546. ISSN 0049-4747

Full text not available from this repository.

Official URL: http://dx.doi.org/10.1007/s11250-006-4437-x

Abstract

This study aimed to determine the effect of intranasal exposure to low doses of Pasteurella multocida B:2 on survival of goats challenged with high doses of the same organism. Eighteen goats were selected and divided into three groups. Goats of group 1 were exposed intranasally twice, with a two-week interval, to 7 × 106 cfu/ml of live P. multocida B:2. Goats of group 2 were not exposed to P. multocida B:2 but were kept together with the exposed group 1. Goats of group 3 remained as unexposed controls and were kept separated from the other two groups. Serum samples were collected at weekly intervals to determine the antibody levels. At week 5 post exposure, all goats were challenged subcutaneously with 3.7 × 1010 cfu/ml of live P. multocida B:2. Following challenge exposure, 8 (67%) goats (4 goats from each of groups 1 and 2) were killed owing to haemorrhagic septicaemia. Four goats were killed peracutely within 48 h post challenge, while the other four goats were killed acutely between 2 and 4 days post challenge. None of the goats of group 3 were killed for haemorrhagic septicaemia. Goats of groups 1 and 2 showed significantly (p < 0.05) higher antibody levels following the first intranasal exposure to P. multocida B:2. However, only group 1 retained the significantly (p < 0.05) high antibody levels following a second intranasal exposure, and remained significantly (p < 0.05) higher than groups 2 and 3 at the time of challenge. P. multocida B:2 was successfully isolated from various organs of goats that were killed between 1 and 4 days post challenge.

Item Type:Article
Keyword:Intranasal, Pasteurella multocida B:2, Goat
Faculty or Institute:Faculty of Veterinary Medicine
Publisher:Springer Science + Business Media B.V. 2007
DOI Number:10.1007/s11250-006-4437-x
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s11250-006-4437-x
ID Code:5555
Deposited By: Azizan Arshad
Deposited On:14 Apr 2010 06:34
Last Modified:30 Jul 2010 04:26

Repository Staff Only: Edit item detail

Document Download Statistics

This item has been downloaded for since 14 Apr 2010 06:34.

View statistics for "Protective effect following intranasal exposure of goats to live Pasteurella multocida B:2"


Universiti Putra Malaysia Institutional Repository

Universiti Putra Malaysia Institutional Repository is an on-line digital archive that serves as a central collection and storage of scientific information and research at the Universiti Putra Malaysia.

Currently, the collections deposited in the IR consists of Master and PhD theses, Master and PhD Project Report, Journal Articles, Journal Bulletins, Conference Papers, UPM News, Newspaper Cuttings, Patents and Inaugural Lectures.

As the policy of the university does not permit users to view thesis in full text, access is only given to the first 24 pages only.