UPM Institutional Repository

Percentage of haemoglobin variants detected during HbA1c analysis in Hospital Kuala Lumpur


Citation

Samsudin, Intan Nureslyna and Md Noor, Sabariah and Lim, C. R. and Wan Salleh, Wan Nor Syafiqah and Chen, D. R. and Choy, S. Y. and Othman, Nor'Ashikin (2013) Percentage of haemoglobin variants detected during HbA1c analysis in Hospital Kuala Lumpur. Malaysian Journal of Medicine and Health Sciences, 9 (2). pp. 13-17. ISSN 1675-8544

Abstract

HbA1c is an established index of glycaemic control and correlates strongly with risk of chronic diabetic complications. However, the accuracy of HbA1c measurement can be affected by many factors, among which is the presence of haemoglobin (Hb) variants. The aim of the study was to determine the percentage of Hb variant detected during HbA1c monitoring in Hospital Kuala Lumpur. The study also analysed non-reportable HbA1c results in the presence of Hb variants. A cross-sectional study using retrospective data of HbA1c results over five months’ period was analysed on Biorad Variant II Turbo, a high performance liquid chromatography (HPLC) assay. The Hb variants were grouped either as HbS, HbC, others (Hb variant apart from HbS or C), and a combination of HbS or C with Others. A total of 11,904 patients were included. Only 2.3% (273) had Hb variants; HbS trait (10.3%), others (89%), and the combination of HbS trait with others (0.7%). No patient with HbC variant or its combination was found. Only 2.2% of those with Hb variant had non-reportable HbA1c. Although the percentage of Hb variants detected during HbA1c analysis and non-reportable HbA1c results were low, their presence should be noted.


Download File

[img]
Preview
PDF (Article)
Percentage of haemoglobin variants detected during HbA1c analysis in Hospital Kuala Lumpur.pdf

Download (89kB) | Preview

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
Keywords: HbA1c; Haemoglobin variant; HPLC; Biorad Variant II Turbo
Depositing User: Mohd Hafiz Che Mahasan
Date Deposited: 18 Dec 2015 00:26
Last Modified: 18 Dec 2015 00:26
URI: http://psasir.upm.edu.my/id/eprint/41363
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item