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An approach of zirconium oxide/polyethylene glycol nanocomposite film on screen printed carbon electrode and its application in glucose determination

Ahmad, Nor Monica and Abdullah, Jaafar and Ramli, Noor Izaanin and Abd Rahman, Samsulida and Azmi, Nur Ellina and Ariffin, Nurhayati (2014) An approach of zirconium oxide/polyethylene glycol nanocomposite film on screen printed carbon electrode and its application in glucose determination. Sensor Letters, 12 (11). pp. 1590-1596. ISSN 1546-198X; ESSN:1546-1971

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Abstract

An amperometric biosensor for the quantitative measurement of glucose is reported. The biosensor is based on a biocomposite that is homogeneous and easily prepared. This biocomposite is made of polyethylene glycol (PEG), Cetyl trimethylammonium bromide (CTAB), glucose oxidase (GOx), and zirconium oxide (ZrO2) nanoparticles. Effect of applied potential, pH, nanocomposite layer, ratio of zirconium oxide nanoparticles (ZrO2) to polyethylene glycol (PEG), concentration of ferrocenecarboxaldehyde (Fc) and concentration of enzyme that governed the analytical performance of the biosensor have been studied. The biosensor was applied to detect glucose with a linear calibration range from 0.1 mM to 12 mM and limit of detection 0.04 mM. The variation coefficient (RSD) for repeatability was 7.5% for ten successive assays while 6.01% (n = 5) for reproducibility test demonstrating that the biosensor fabrication process is reproducible. Common interfering compounds on the amperometric response of the sensor were investigated and discussed herein.

Item Type:Article
Keyword:Biosensor; Polyethylene glycol; Zirconium oxide
Faculty or Institute:Faculty of Science
Publisher:American Scientific Publishers
DOI Number:10.1166/sl.2014.3381
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1166/sl.2014.3381
ID Code:36391
Deposited By: Nabilah Mustapa
Deposited On:24 Jun 2015 15:24
Last Modified:21 Aug 2015 11:17

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