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The influence of fasting insulin level in post-gestational diabetes mellitus women receiving low-glycaemic-index diets


Citation

Abdul Ghani, Rohana and Shyam, Sangeetha and Arshad, Fatimah and Abdul Wahab, Norasyikin and Chinna, Karuthan and Safii, Nik Shanita and Mohd Yusof, Barakatun Nisak and Kamaruddin, Nor Azmi (2014) The influence of fasting insulin level in post-gestational diabetes mellitus women receiving low-glycaemic-index diets. Nutrition & Diabetes, 4. art. no. e107. pp. 1-5. ISSN 2044-4052

Abstract / Synopsis

Post-gestational diabetes mellitus (GDM) women are recommended weight loss to manage increased cardio-metabolic risks. We investigated the effects of lowering diet glycaemic index (GI) on fasting blood glucose (FBG), serum lipids, body weight and composition of post-GDM women with varying fasting insulin levels (INS). Seventy-seven Asian, non-diabetic women with previous GDM (aged 20-40 years, mean BMI: 26.4±4.6 kgm-2) were recruited. At baseline, 20 subjects with INS <2 μIU ml-1 and 18 with INS ≥2 μIU ml-1 received conventional dietary recommendations (CHDR) only. CHDR emphasised energy and fat intake restriction and encouraged increase in dietary fibre intakes. Twenty-four subjects with INS <2 μIU ml-1 and 15 with INS ≥2 μIU ml-1, in addition to CHDR, received low-GI education (LGI). Changes in FBG, serum lipids, body weight and body composition were evaluated. Subjects with INS <2 μIU ml-1 had similar outcomes with both diets. After 1 year, subjects with INS ≥2 μIU ml-1 who received LGI education had reductions in FBG and triglycerides. Subjects who received CHDR observed increase in both FBG and triglycerides (P<0.05). Among all subjects, diet GI was lower and dietary fibre intakes were higher in LGI compared with CHDR subjects (all P<0.05). Thus, in Asian post-GDM women with normal/higher INS, adding low-GI education to CHDR improved management of FBG and triglycerides. © 2014 Macmillan Publishers Limited All rights reserved.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: 10.1038/nutd.2014.5
Publisher: Nature Publishing Group
Keywords: Gestational diabetes mellitus; Glycaemic index; Type 2 diabetes mellitus; Prevention; Fasting insulin; Diet
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 04 Feb 2016 10:36
Last Modified: 04 Feb 2016 10:36
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1038/nutd.2014.5
URI: http://psasir.upm.edu.my/id/eprint/35733
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