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Synthesis and antibacterial study of aaptamine derivatives

Abdul Rashid, Fatin Nur Ain and Asari, Asnuzilawati and Mohamad, Habsah and Mohd Nor, Siti Mariam (2014) Synthesis and antibacterial study of aaptamine derivatives. Asian Journal of Chemistry, 26 (20). pp. 6903-6907. ISSN 0970-7077

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Aaptamine is a bioactive marine alkaloid containing a unique of 1H-benzo[de][1,6]naphthyridine skeleton. Aaptamine was isolated from marine sponge, Aaptos aaptos and was proposed as starting material for semi-synthetic modifications. A series of aaptamine derivatives were synthesized which consisted of 1,4-dialkyl (2-7), 4-alkyl (8-10) and 9-O-butyryl-1,4-dialkyl (11-16) aaptamine derivatives. Each derivative was characterized by FT-IR, UV-visible, NMR and MS. The synthesized compounds were evaluated for their antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Bacillus cereus, Staphylococcus aureus and Micrococcus sp. bacterial strains using the disc-diffusion method. Some of the derivatives showed potent antibacterial activity against certain bacterial strains. - See more at:

Item Type:Article
Keyword:Aaptamine; Antibacterial; Disc-diffussion method
Faculty or Institute:Faculty of Science
Publisher:Chemic Publishing Company
DOI Number:10.14233/ajchem.2014.17377
ID Code:35563
Deposited By: Nurul Ainie Mokhtar
Deposited On:14 Jan 2016 13:06
Last Modified:14 Jan 2016 13:06

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