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Skeletal malformation of fetuses from pregnant Sprague Dawley rats fed Jatropha curcas crude oil (JCO)

Abdul Mutalib, Noor Haziyah and Samat, Yon Thannia and Sukardi, Sabrina (2014) Skeletal malformation of fetuses from pregnant Sprague Dawley rats fed Jatropha curcas crude oil (JCO). European International Journal of Science and Technology, 3 (9). pp. 54-60. ISSN 2304-9693

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Official URL: http://www.eijst.org.uk/December2014

Abstract

Studies on the teratogenicity effects of Jatropha curcas has been reported in pregnant rats. This study was conducted to observe whether feeding Jatropha curcas seeds crude oil (JCO)to pregnant rats during early and late gestation will cause fetal skeletal malformations. A hundred sexually mature female rats were divided equally into 2 groups: early and late gestation. Each group was then subdivided equally into 5 groups: positive control (retinylpalmitate), vehicle control (corn oil), low dose (0.175ml/kg), medium dose (0.35ml/kg) and high dose (0.7ml/kg) of JCO. Rats were mated overnight and positive pregnant ratswere treated on days 1-7 (early group) and days 8-14 (late group). Rats were sacrificed on day 21 of pregnancy. Fetuses were processed accordingly and any skeletal malformations were recorded. Data show fetuses in high treatment group were significantly smaller as compared to other groups. Skeletal abnormalities in fetuses from all JCO treated groups were observed suggesting fetotoxicity.

Item Type:Article
Keyword:Jatropha curcas crude oil; Teratogenicity; Skeletal malformation; Fetus; Pregnant Sprague dawley rats
Publisher:Centre for Enhancing Knowledge
ID Code:35390
Deposited By: Nurul Ainie Mokhtar
Deposited On:06 Jan 2016 11:37
Last Modified:06 Jan 2016 11:37

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