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Newcastle disease virus activated human peripheral blood mononuclear cells and their use in cancer therapy.

Noorjahan Banu Mohammed Alitheen.. (2010) Newcastle disease virus activated human peripheral blood mononuclear cells and their use in cancer therapy.

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Abstract

This invention provides a method for immune activation of human peripheral blood mononuclear cells (PBMC) by treatment with immunogens derived from New Castle Disease virus (NDV). The invention describes a method of activation of PBMC by NDV, the activated PBMCs produced by the inventive method as well as pharmaceutical compositions and vaccines comprising the same. Further embodiments of the invention relate to the use of NDV derived immunogens and the inventive activated PBMCs in immunetheraphy of proliferative diseases - such as cancer. The invention finally provides a method for killing target cells, preferably cancer cells, by co-culturing the target cells together with the inventive activated PBMCs.

Item Type:Patent
Keyword:Newcastle disease; Peripheral blood mononuclear cell; Virus; Cancer.
Faculty or Institute:Faculty of Biotechnology and Biomolecular Sciences
Application Number:PI2010700088
Filing Date:2010-11-30
ID Code:32058
Deposited By: Nurul Ainie Mokhtar
Deposited On:03 Sep 2014 14:30
Last Modified:03 Sep 2014 14:30

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