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Tamoxifen-loaded nanostructured lipid carrier as a drug delivery system: characterization, stability assessment and cytotoxicity


Citation

How, Chee Wun and Rasedee, Abdullah and Manickam, Sivakumar and Rosli, Rozita (2013) Tamoxifen-loaded nanostructured lipid carrier as a drug delivery system: characterization, stability assessment and cytotoxicity. Colloids and Surfaces B: Biointerfaces, 112 (1). pp. 393-399. ISSN 0927-7765; ESSN: 1873-4367

Abstract

Cancer nanotherapeutics is beginning to overwhelm the global research and viewed to be the revolutionary treatment regime in the medical field. This investigation describes the development of a stable nanostructured lipid carrier (NLC) system as carrier for Tamoxifen (TAM). The TAM-loaded NLC (TAM-NLC) developed with 200 mg of TAM showed a spherical particle with the size of 46.6 nm, polydispersity index of 0.267, entrapment efficiency of 99.74% and with the zeta potential of -23.78 mV. Besides, the equivalent cytotoxicity of TAM and TAM-NLC to human (MCF-7) and mice (4T1) mammary breast cancer cell lines were observed. Incubating the formulation at the physiological pH resulted into reduced Ostwald ripening rate but without any significant change in the absorptivity. When coupled with the measurements of zeta potential and Ostwald ripening rate, the absorbance assay may be used to predict the long-term stability of drug-loaded nanoparticle formulations. The results of the study also suggest that TAM-NLC is a promising drug delivery system for breast cancer therapy. This is the first encouraging report on the in vitro effect of TAM-NLC against human and mouse mammary adenocarcinoma cell lines.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
Institute of Bioscience
DOI Number: https://doi.org/10.1016/j.colsurfb.2013.08.009
Publisher: Elsevier BV
Keywords: Lipid nanoparticles; Tamoxifen; Absorbance; Ostwald ripening; Mammary adenocarcinoma cell line; Drug delivery; Nanostructured lipid carrrier.
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 22 May 2015 02:27
Last Modified: 10 Sep 2015 07:10
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.colsurfb.2013.08.009
URI: http://psasir.upm.edu.my/id/eprint/29683
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