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Evaluation of anticoagulant property of aqueous and Ethanolic Extracts of Morinda citrifolia

Abdul Karim, Mohd Arif and Md Noor, Sabariah and Seman, Zainina and Mohd Tohit, Eusni Rahayu and Idris, Faridah (2013) Evaluation of anticoagulant property of aqueous and Ethanolic Extracts of Morinda citrifolia. International Journal of Tropical Medicine, 8 (1). pp. 1-5. ISSN 1816-3319; ESSN: 1818-779X

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Abstract

Anticoagulant is an agent used to treat patients with cardiovascular diseases by preventing new clots formation. It works by inhibiting blood from clotting, therefore preventing progression of thrombosis. Heparin, the animal based polysaccharides is a widely used anticoagulant has many adverse effects. This study aimed to evaluate the effects of Morinda citrifolia Aqueous Extract (MCAE) and Ethanolic Extract (MCEE) on plasma coagulation in vitro. Platelet Poor Plasma (PPP) from fifty healthy volunteers was incubated with different concentrations of extracts (10, 20, 30, 40 and 50 mg mL-1) and subjected for clotting assays of Prothrombin Time (PT) and Activated Partial Thrombosplastin Time (APTT). The samples that been incubated by MCAE and MCEE showed prolongation of PT and APTT. These findings indicated that Morinda citrifolia extracts has anticoagulant effect in vitro and also suggest that it may become a potential plant based anticoagulant which is should be effective and safe for clinical need in dealing with patient with cardiovascular disorders.

Item Type:Article
Keyword:Morinda citrifolia; Plant based polysaccharide; Coagulation assay; Anticoagulant activivty; MCAE
Faculty or Institute:Faculty of Medicine and Health Science
Publisher:Medwell Journals
ID Code:29641
Deposited By: Nurul Ainie Mokhtar
Deposited On:25 May 2015 10:54
Last Modified:10 Sep 2015 14:22

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