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Pattern of calcification on CT and FDG-PET of a rare perineural mantle cell lymphoma: a potential of non-histological imaging marker

Ahmad Saad, Fathinul Fikri and Shakher, Ramdave and Nordin, Abdul Jalil (2016) Pattern of calcification on CT and FDG-PET of a rare perineural mantle cell lymphoma: a potential of non-histological imaging marker. Pertanika Journal of Science & Technology, 24 (2). pp. 397-401. ISSN 0128-7680; ESSN: 2231-8526

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Official URL: http://www.pertanika.upm.edu.my/Pertanika%20PAPERS...

Abstract

The presence of calcification in a particular FDG-avid soft tissue lesion may at times present uncertainty regarding the clinical course of the disease pathology. Calcific deposits are not specific for either benign or malignant aetiologies (Brant et al., 2010). Altered glucose metabolism with associated calcification may underpin underlying aggressive pathophysiology with necrosis as sequelae. Mantle Cell Lymphoma (MCL) is a subtype of non-Hodgkin’s lymphoma. It is a rare B-cell NHL that is prevalent in men over the age of 60. The disease may be aggressive but it can also behave in a more indolent fashion in some patients. MCL comprises about 5% of all NHLs. The disease is called Mantle Cell Lymphoma because the tumour cells originally come from the ‘mantle zone’ of the lymph node (Zhou et al., 2004). Pretreatment Hodgkin’s lymphoma with calcification may masquerade as other second primary pathologies, e.g. extraosseous osteosarcoma or myositis ossificans (Apter et al., 2002; Korek-Amorosa et al., 1974). A calcified perineural lymphoma prior to treatment is exceedingly rare and calcification usually occurs one to five years after chemotherapy or radiation therapy with an incidence of 2% (Apter et al., 2002). This case documents how the manifestation of a rare malignant perineural mantle cell lymphoma may be indistinguishable from other pathological entities based on its pattern of distribution in a combined FDG-PET-CT study.

Item Type:Article
Keyword:Calcification; FDG; Mantle cell lymphoma; Perineural; PET-CT
Faculty or Institute:Centre For Diagnostic Nuclear Imaging
Publisher:Universiti Putra Malaysia Press
ID Code:29373
Deposited By: Nurul Ainie Mokhtar
Deposited On:03 Aug 2016 10:04
Last Modified:03 Aug 2016 10:04

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