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Theobroma cacao: review of the extraction, isolation, and bioassay of its potential anti-cancer compounds


Citation

Baharum, Zainal and Md. Akim, Abdah and Yap, Taufiq Yun Hin and Abd Hamid @ Abdul Razak, Roslida and Kasran, Rosmin (2016) Theobroma cacao: review of the extraction, isolation, and bioassay of its potential anti-cancer compounds. Tropical Life Sciences Research, 27 (1). pp. 21-42. ISSN 1985-3718; ESSN: 2180-4249

Abstract

Plants have been a good source of therapeutic agents for thousands of years; an impressive number of modern drugs used for treating human diseases are derived from natural sources. The Theobroma cacao tree, or cocoa, has recently garnered increasing attention and become the subject of research due to its antioxidant properties, which are related to potential anti-cancer effects. In the past few years, identifying and developing active compounds or extracts from the cocoa bean that might exert anti-cancer effects have become an important area of health- and biomedicine-related research. This review provides an updated overview of T. cacao in terms of its potential anti-cancer compounds and their extraction, in vitro bioassay, purification, and identification. This article also discusses the advantages and disadvantages of the techniques described and reviews the processes for future perspectives of analytical methods from the viewpoint of anti-cancer compound discovery.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Science
Publisher: Penerbit Universiti Sains Malaysia
Keywords: Anti-cancer; Natural products; Theobroma cacao
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 20 Jun 2016 06:49
Last Modified: 20 Jun 2016 06:49
URI: http://psasir.upm.edu.my/id/eprint/29166
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