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Characterization and stability of nanostructured lipid carriers as drug delivery system

Abbasalipourkabirreh, Roghayeh and Salehzadeh, Aref and Abdullah, Rasedee (2012) Characterization and stability of nanostructured lipid carriers as drug delivery system. Pakistan Journal of Biological Sciences, 15 (3). pp. 141-146. ISSN 1028-8880; ESSN: 1812-5735

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Abstract

Recently more focus has been put to the development of innovative drug-delivery systems that includes polymer nanoparticles, emulsions and liposomes and solid lipid nanoparticles (SLNs). The SLNs have been proposed to be an alternative colloidal drug delivery system. The aim of this study was preparation and characterization of solid lipid nanoparticle (SLN) using varieties of emulsifier for encapsulation of the drug with poor water solubility. In these study four types of solid lipid nanoparticles were prepared based on different compositions of palm oil (S154) and lecithin (Lipoid 100) using the high pressure homogenization method. The SLN formulation had the following (palm oil+lecithin) compositions: SLN-01 (90+10%, respectively), SLN-02 (80+20%, respectively), SLN-03 (70+30%, respectively) and SLN-04 (60+40%, respectively). The SLNs were characterized and the optimum stability factors for one year storage determined. The parameters used to characterize the SLNs were particle size and polydispersity index (particle sizer), zeta potential (zetasizer), crystallinity (differential scanning calorimetry and wide angle X-ray diffraction), ultrastructure (transmission electron microscopy). Varying the palm oil and lecithin compositions resulted in SLNs of variable sizes and zeta potentials. The particle sizes of SLN-01, SLN-02, SLN-03 and SLN-04 were 298.40±11.80, 255.40±3.20, 145.00±3.39 and 273.00±86.50 nm, respectively, while the zeta potentials were -19.44±60.00, -19.50±1.80, -17.83±10.00 and -13.33±2.30 mV, respectively. Thermoanalysis and X-ray diffraction analysis showed that the SLNs had lower crystallinity than bulk lipid. The SLNs were generally round and uniform in shape under transmission electron microscopy. The SLN dimensional data suggested they had high quality physicochemical characteristics, which are conducive for the loading of poor water solubility drugs.

Item Type:Article
Keyword:Characterizations; Colloidal system; Drug delivery; Solid lipid nanoparticles
Faculty or Institute:Institute of Bioscience
Publisher:Asian Network for Scientific Information
DOI Number:10.3923/pjbs.2012.141.146
Altmetrics:http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3923/pjbs.2012.141.146
ID Code:27063
Deposited By: Azizan Arshad
Deposited On:08 Jan 2014 16:32
Last Modified:27 Apr 2016 16:02

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