Attenuated bacteria for use in a vaccine.
Mohd. Zamri Saad. (2007) Attenuated bacteria for use in a vaccine.
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The present invention relates to an attenuated bacterium for use as a medicament which stimulates protective immunity against normal growth of pathogenic pasteurella bacteria. The invention also relates to immunogenic preparations including vaccines against disease caused by infection by a virulent pasteurella strain and tools for the generation of immunological and diagnostic reagents. Further, the present invention relates to live attenuated recombinant bacteria carrying a gene and vaccines based thereon that can be administered to animals, particularly ruminants to provide protective immunity against challenge by pasteurella bacteria. Also disclosed are the bacterium polypeptide and includes polypeptide sequences, gene sequences encoding the polypeptide, vectors to contain the said sequences, and host cells transformed with the said vectors which include nucleoticle sequences of the polypepticle sequences.
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