Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene) hydrazinecarbodithioate.

Citation

Ravoof, Thahira Begum S A and Crouse, Karen Anne and Mohamed Tahir, Mohamed Ibrahim and Rosli, Rozita and Watkin, David John and How, Fiona Ni Foong (2011) Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene) hydrazinecarbodithioate. Journal of Chemical Crystallography, 41 (4). pp. 491-495. ISSN 1074-1542; ESSN:1572-8854

Abstract

A new tridentate nitrogen–sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical and spectroscopic techniques. The X-ray crystallographic analysis of the Schiff base is reported. The Schiff base crystallized in a monoclinic system with a space group of P 21/n, with crystal cell parameters a = 10.8128 (2) Å, b = 9.3832 (2) Å, c = 18.0352 (4) Å, β = 97.1311 (9)°. The Schiff base was found to be inactive against selected microbes and two breast cancer cell lines (MCF-7 = Human breast cancer cell line with positive estrogen receptor and MDA-MB-231 = Human breast cancer cell line with negative estrogen receptor).

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Science
DOI Number:	https://doi.org/10.1007/s10870-010-9907-3
Publisher:	Springer
Keywords:	Biological activity; Di-2-pyridylketone Schiff base; Dithiocarbazate.
Depositing User:	Nur Farahin Ramli
Date Deposited:	25 Nov 2013 04:20
Last Modified:	30 Oct 2015 07:46
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s10870-010-9907-3
URI:	http://psasir.upm.edu.my/id/eprint/25247
Statistic Details:	View Download Statistic

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