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In vitro antiplasmodial activity and cytotoxicity of ten plants used as traditional medicine in Malaysia.

Abdullah, Wan Omar and Unyah, Ngah Zasmy and Awang Hamat, Rukman and Omar, Baharudin and Abd Ghani, Mohd Kamel and Mohammad Rayani, and Hatam, Gholam Reza (2011) In vitro antiplasmodial activity and cytotoxicity of ten plants used as traditional medicine in Malaysia. Malaysian Journal of Health Science, 9 (2). pp. 5-8. ISSN 1675-8161; ESSN: 2289-4535

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Abstract / Synopsis

Dichloromethane and methanolic extracts of each plant were tested for their antiplasmodial activity on chloroquineresistant strain of Plasmodium falciparum (FCB strain), based on lactate dehydrogenase activity. Cytotoxicity was assessed with the MTT test on MRC-5 human diploid embryonic lung cells. Most extracts of ten selected plants used in Malay traditional medicine in Malaysia had activity in vitro. This supports continued investigations of traditional medicine in the search for new antimalarial agent. The compounds responsible for the observed antiplasmodial effects are under investigation.

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Universiti Kebangsaan Malaysia Press
Keywords: Plasmodium falciparum; Plant; Antiplasmodial activity; Cytotoxicity; Malaysia.
Depositing User: Nur Farahin Ramli
Date Deposited: 18 Mar 2014 10:15
Last Modified: 09 Oct 2015 08:52
URI: http://psasir.upm.edu.my/id/eprint/24559

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