Effects of Feeding Oxalic Acid to Pregnant Rats

Abdul Rahman, Sheikh Omar and Schiefer, H. B. (1980) Effects of Feeding Oxalic Acid to Pregnant Rats. Pertanika, 3 (1). pp. 25-31.

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Two studies were carried out. The aim of the pilot study was to find a suitable dose ofoxalic acid to be used in the principal study. Thirty pregnant Wister rats were used in the p'rincipal study divided into three groups of 10 animals each. The animals in two groups received oxalic acid at 0.035 g and 0.045 g per day per animal until parturition. The animals in the third group received normal saline. No abortions, gross malformations or renal oxalosis were observed in the foetuses and newborn in both studies. However changes comparable to tubulonephrosis were observed in the newborn in the group receiving 0.03 gf day in the pilot study. A correlation was observed in the principal study between the dose of oxalic acid and renal oxalosis in the dams as well as differences in litter size. Possible reasons for these observations were discussed

Item Type:Article
Keyword:Pregnant rats, oxalic acid, tubulonephrosis, renal oxalosis
Faculty or Institute:Faculty of Veterinary Medicine
ID Code:2057
Deposited By: Nur Izyan Mohd Zaki
Deposited On:10 Nov 2009 00:23
Last Modified:27 May 2013 06:58

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